B. Insulinoma – Explanation
Multiple endocrine neoplasia
The table below summarises the three main types of multiple endocrine neoplasia (MEN)
| MEN type I | MEN type IIa | MEN type IIb |
| Mnemonic ‘three P’s’: parathyroid (95%): hyperparathyroidism due to parathyroid hyperplasia pituitary (70%) pancreas (50%, e.g. insulinoma, gastrinoma) also: adrenal and thyroid |
phaeochromocytoma medullary thyroid cancer (70%) parathyroid (60%) |
medullary thyroid cancer phaeochromocytoma marfanoid body habitus neuromas |
| MEN1 gene Most common presentation = hypercalcaemia |
RET oncogene | RET oncogene |
MEN is inherited as an autosomal dominant disorder
