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A. Carboxyhaemoglobin – Explanation

Oxygen dissociation curve
  • shifts Left – Lower oxygen delivery – Lower acidity, temp, 2-3 DPG – also HDF, carboxy/methemoglobin
  • shifts Right – Raised oxygen delivery – Raised acidity, temp, 2-3 DPG

Oxygen dissociation curve
The oxygen dissociation curve describes the relationship between the percentage of saturated
hemoglobin and partial pressure of oxygen in the blood. It is not affected by hemoglobin
concentration
Basics

  • shifts to left = for given oxygen tension there is increased saturation of Hb with oxygen i.e.
    decreased oxygen delivery to tissues
  • shifts to right = for given oxygen tension there is reduced saturation of Hb with oxygen i.e.
    enhanced oxygen delivery to tissues
 Shifts to Left = Lower oxygen delivery
  • HDF, methemoglobin, carboxyhemoglobin
  • low [H+] (alkali)
  • low pCO2
  • low 2,3-DPG
  • low temperature
  Shifts to Right = Raised oxygen delivery
  • raised [H+] (acidic)
  • raised pCO2
  • raised 2,3-DPG*
  • raised temperature

 

*2,3-diphosphoglycerate

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