D. Medullary – Explanation
The RET oncogene encodes a receptor tyrosine kinase and is associated with MEN type 2.
Papillary thyroid cancer also appears to be associated with the RET oncogene
Multiple endocrine neoplasia
The table below summarizes the three main types of multiple endocrine neoplasia (MEN)
| MEN type I | MEN type IIa | MEN type IIb |
| Mnemonic ‘three P’s’: parathyroid (95%): hyperparathyroidism due to parathyroid hyperplasia pituitary (70%) pancreas (50%, e.g. insulin | phaeochromocytoma medullary thyroid cancer (70%) parathyroid (60%) | medullary thyroid cancer phaeochromocytoma marfanoid body habitus neuro |
| MEN1 gene Most presentation = hypercalcemia | RET oncogene | RET oncogene |
