D. Fluoxetine – Explanation

Posted by Dr. Irin's Academy
Categories Explanation
Date November 20, 2024

Sexual dysfunction isa common symptom of depression. However, in addition to this, all
antidepressants can cause sexual dysfunction to varying degrees (most commonly
serotonin reuptake inhibitors).

Table 1. Sexual adverse effects of antidepressants

Drug	Prevalence	Type of problem experienced
Selective serotonin reuptake inhibitors (SSRIs)	60-70%	All phases of the sexual response Paroxetine is associated with more erectile dysfunction and vaginal dryness than other SSRIs
Tricyclic antidepressants (TCAs)	30%	Decreased libido, erectile dysfunction, delayed orgasm, and impaired ejaculation
Venlafaxine	70%	Decreased libido, delayed orgasm, and erectile dysfunction. Rarely painful ejaculation and priapism
Mirtazepine	25%	Decreased libido, delayed orgasm, erectiledysfunction, absence of orgasm
Reboxetine	5-10%	Orgasm abnormalities
Duloxetine	46%	Delayed orgasm
Irreversible monoamine oxidase inhibitors (MAOIs)	40%	Decreased libido, erectile dysfunction, delayed orgasm, and impaired ejaculation Moclobemide is less likely to cause sexual dysfunction compared with older MAOIs (4% versus 40%)

Dr. Irin's Academy